Volume 2
Management of Side Effects in Chimeric Antigen Receptor (CAR) T-Cell Therapy: Current Approaches and Future Trends
Authors
Nasrin Abdollahzadeh
Abstract
The use of CAR T-cell therapy has revolutionized cancer treatment by harnessing the immune system to target and eliminate cancerous cells. However, this breakthrough therapy is associated with significant side effects, such as Cytokine Release Syndrome (CRS) and neurotoxicity, which pose challenges to patient safety and care. Effectively managing these adverse effects is essential for improving treatment outcomes. Artificial intelligence (AI) has emerged as a transformative tool in addressing these challenges by facilitating precise patient stratification, predicting treatment responses, and optimizing CAR T-cell design to minimize toxicities while maintaining therapeutic efficacy. Additionally, AI enhances manufacturing processes, streamlining production and improving scalability. These advancements highlight the critical role of AI in not only improving the safety of CAR T-cell therapy but also expanding its accessibility to a broader patient population.
Keyword: CRS, neurotoxicity, side effect management, artificial intelligence
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